Is there new evidence linking long-term estrogen use to breast cancer?

A customer shared with us that her doctor believes estrogen is safe and has significantly alleviated menopausal discomfort for millions of women. According to her doctor, studies linking estrogen to cancer risk are flawed. Consequently, she has decided to use estrogen regardless of what the research indicates.

We hold medical professionals in high regard and have no intention of disputing her decision. Our priority is to support our customers in making informed health decisions, respecting the guidance they receive from their healthcare providers.

It's important to recognize that doctors, like all individuals, can have biases. Today, the most sophisticated and powerful artificial intelligence (AI) systems are available. They can aggregate all the knowledge currently accessible to humans and are designed to be unbiased. Let us ask the unbiased AI, ChatGPT, this question.

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In ChatGPT4 query box, we typed the question "Is there new evidence linking long-term estrogen use to breast cancer?"

Below is the answer:

"Recent research has provided new insights into the link between long-term estrogen use and breast cancer. A study highlighted by the Harvard Gazette indicates that estrogen plays a more direct role in the development of breast cancer than previously understood. The research suggests that estrogen can directly induce genomic rearrangements leading to cancer, making it both a catalyst for and a direct cause of the disease. This new understanding of estrogen's role in breast cancer could have implications for the design of future treatments and diagnostic tests.

Additionally, comprehensive data analysis from various studies, as summarized by Susan G. Komen, reinforces the notion that the use of menopausal hormone therapy (MHT), which includes estrogen, is linked to an increased risk of breast cancer. The risk varies depending on the duration of use, with longer periods of estrogen alone or combined estrogen-progestin therapy showing an increased risk. For example, studies have shown that current use of MHT for more than 10 years is associated with a higher risk compared to shorter durations. However, it's also noted that for some forms of breast cancer, the risk may differ, highlighting the complex relationship between hormone therapy and breast cancer risk.

These findings underscore the importance of personalized medical advice and careful consideration of the benefits and risks of long-term estrogen therapy, especially for women at higher risk of breast cancer."

Here is the link to the article from Harvard Gazette:

Feb 20, 2024

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